What pde5 Inhibitors Are and How They Work

Pde5 inhibitors relax the muscles in the penis in order to facilitate blood flow and lead to erection. They stop the enzyme Phosphodiesterase-5’s release in the penis’s smooth muscle cells. Nitric oxide is released into the penis by nerves and endothelial cells. The guanylyl cyclase produces cGMP and lowers the levels of calcium between cells. This leads to relaxation of the arterial and trabecular smooth muscle, resulting into arterial dilatation and venous constriction, which leads to erection.

Erection is a natural reaction to sexual arousal. Erectile dysfunction results from psychological or physical blockage which constricts blood-flow to the penis.

The development of PDE5 inhibitors is the result on ample research on physiological processes behind erectile dysfunction. It has established that the main cause of erectile difficulties lies in the restriction of blood access to the muscle cells on which erection depends. With a combination of blood pressure increase, muscle and arterial dilation and increase in testosterone levels, pde5 inhibitors enable smooth erectile functioning.

Types Of pde5 Inhibitors

how-do-sildenafil-and-tadalafil-workThe most common types of PDE5 inhibitors include:

  • Viagra (also known as Sildenafil)
  • Cialis (also known as Tadalafil)
  • Levitra (also known as Vardenafil)

Cialis and Levitra are the most recent developments in PDE5 research. Like Viagra, they aid in relaxing the body in a manner that welcomes sexual arousal with facilitated blood flow to smooth muscle cells in the penis. The process is relatively constant with each one of these drugs, requiring on average 30 to 45 minutes to see notable results.

Viagra, Cialis and Levitra Comparisons

The main difference in these drugs lies in the duration of their effects. Whilst they all have secondary influence (ease of erection greater than normal, but not as strong as when primarily affected by the drug) that may last up to several days, the immediate erection lasts about 4 hours after taking Viagra, as opposed to 5 with Levitra and upwards of 12 hours with Cialis.

Why Pick One Over The Other?

Cialis is known to have the longest-lasting results but to have side-effects such as runny noses and mild headaches. Viagra and Levitra, on the other hand, have virtually no side-effects (though they do not last as long as Cialis). The drug you initially choose will depend on your individual preferences. Furthermore, it is advised to consult a doctor to establish whether you have no underlying condition that will lead to an adverse reaction to the drug at hand.

Should you be unresponsive to a drug, you may safely switch to another as long as you observe the prescribed dosage.